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ClinVar includes an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice web site are a relatively common explanation for aberrant splicing (PMID: 17576681, 9536098). Algorithms made to forecast the outcome of sequence variations on RNA splicing counsel that this variant could produce or strengthen a splice web page. In summary, the readily available evidence is currently inadequate to ascertain the role of this variant in disease. Therefore, it's been classified to be a Variant of Uncertain Importance. (a lot less)

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Aberrant five' splice internet sites in human ailment genes: mutation pattern, nucleotide construction and comparison of computational equipment that predict their utilization.

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Stars represent the combination evaluate position, or the extent of overview supporting the mixture germline classification for this VCV history.

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